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Sex Differences in Working Memory after Mild Traumatic Brain Injury: A Functional MR Imaging Study.
Hsu, Hui-Ling; Chen, David Yen-Ting; Tseng, Ying-Chi; Kuo, Ying-Sheng; Huang, Yen-Lin; Chiu, Wen-Ta; Yan, Feng-Xian; Wang, Wei-Shuan; Chen, Chi-Jen.
Afiliación
  • Hsu HL; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Chen DY; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Tseng YC; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Kuo YS; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Huang YL; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Chiu WT; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Yan FX; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Wang WS; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
  • Chen CJ; From the Department of Diagnostic Radiology and Brain and Consciousness Research Center, Taipei Medical University Shuang-Ho Hospital, No. 291, Jhong-Jheng Road, 235 Jhonghe District, New Taipei City, Taiwan, ROC.
Radiology ; 276(3): 828-35, 2015 Sep.
Article en En | MEDLINE | ID: mdl-25919663
PURPOSE: To evaluate sex differences in mild traumatic brain injury (MTBI) with working memory functional magnetic resonance (MR) imaging. MATERIALS AND METHODS: Research ethics committee approval and patient written informed consent were obtained. Working memory brain activation patterns were assessed with functional MR imaging in 30 patients (15 consecutive men and 15 consecutive women) with MTBI and 30 control subjects (15 consecutive men and 15 consecutive women). Two imaging studies were performed in patients: the initial study, which was performed within 1 month after the injury, and a follow-up study, which was performed 6 weeks after the first study. For each participant, digit span and continuous performance testing were performed before functional MR imaging. Clinical data were analyzed by using Kruskal-Wallis, Mann-Whitney U, Wilcoxon signed rank, and Fisher exact tests. Within- and between-group differences of functional MR imaging data were analyzed with one- and two-sample t tests, respectively. RESULTS: Among female participants, the total digit span score was lower in the MTBI group than in the control group (P = .044). In initial working memory functional MR imaging studies, hyperactivation was found in the male MTBI group and hypoactivation was found in the female MTBI group compared with control male and female groups, respectively. At the 6-week follow-up study, the female MTBI group showed persistent hypoactivation, whereas the male MTBI group showed a regression of hyperactivation at visual comparison of activation maps. The male MTBI group was also found to have a higher initial ß value than the male control group (P = .040), and there was no significant difference between the male MTBI group and the male control group (P = .221) at follow-up evaluation, which was comparable to findings on activation maps. In the female MTBI group, average ß values at both initial and follow-up studies were lower compared with those in the female control group but were not statistically significant (P = .663 and P = .191, respectively). CONCLUSION: Female patients with MTBI had lower digit span scores than did female control subjects, and functional MR imaging depicted sex differences in working memory functional activation; hypoactivation with nonrecovery of activation change at follow-up studies may suggest a worse working memory outcome in female patients with MTBI.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Imagen por Resonancia Magnética / Factores Sexuales / Memoria a Corto Plazo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2015 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Imagen por Resonancia Magnética / Factores Sexuales / Memoria a Corto Plazo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2015 Tipo del documento: Article