DNA replication origin activation in space and time.
Nat Rev Mol Cell Biol
; 16(6): 360-74, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25999062
ABSTRACT
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
Fase G1
/
Fase S
/
Origen de Réplica
/
Replicación del ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia