N-Heterocyclic Carbene-Catalyzed Oxidative Annulations of α,ß-Unsaturated Aldehydes with Hydrazones: Selective Synthesis of Optically Active 4,5-Dihydropyridazin-3-ones and Pyridazin-3-ones.
J Org Chem
; 80(12): 6350-9, 2015 Jun 19.
Article
en En
| MEDLINE
| ID: mdl-26019007
ABSTRACT
A novel and efficient method for the highly enantioselective synthesis of chiral 4,5-dihydropyridazin-3-one derivatives has been developed based on the chiral N-heterocyclic carbene-catalyzed oxidative annulation between α,ß-unsaturated aldehydes and hydrazones. Meanwhile, the selective synthesis of either 4,5-dihydropyridazin-3-ones or pyridazin-3-one derivatives from the same reactants has been achieved by simply varying catalytic and reaction conditions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piridazinas
/
Aldehídos
/
Compuestos Heterocíclicos
/
Metano
Idioma:
En
Revista:
J Org Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
China