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Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Schumacher, Fredrick R; Schmit, Stephanie L; Jiao, Shuo; Edlund, Christopher K; Wang, Hansong; Zhang, Ben; Hsu, Li; Huang, Shu-Chen; Fischer, Christopher P; Harju, John F; Idos, Gregory E; Lejbkowicz, Flavio; Manion, Frank J; McDonnell, Kevin; McNeil, Caroline E; Melas, Marilena; Rennert, Hedy S; Shi, Wei; Thomas, Duncan C; Van Den Berg, David J; Hutter, Carolyn M; Aragaki, Aaron K; Butterbach, Katja; Caan, Bette J; Carlson, Christopher S; Chanock, Stephen J; Curtis, Keith R; Fuchs, Charles S; Gala, Manish; Giovannucci, Edward L; Gogarten, Stephanie M; Hayes, Richard B; Henderson, Brian; Hunter, David J; Jackson, Rebecca D; Kolonel, Laurence N; Kooperberg, Charles; Küry, Sébastien; LaCroix, Andrea; Laurie, Cathy C; Laurie, Cecelia A; Lemire, Mathieu; Levine, David; Ma, Jing; Makar, Karen W; Qu, Conghui; Taverna, Darin; Ulrich, Cornelia M; Wu, Kana; Kono, Suminori.
Afiliación
  • Schumacher FR; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Schmit SL; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Jiao S; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
  • Edlund CK; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Wang H; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Zhang B; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
  • Hsu L; Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China.
  • Huang SC; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Fischer CP; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Harju JF; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.
  • Idos GE; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.
  • Lejbkowicz F; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Manion FJ; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.
  • McDonnell K; Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.
  • McNeil CE; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.
  • Melas M; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Rennert HS; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Shi W; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Thomas DC; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.
  • Van Den Berg DJ; Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.
  • Hutter CM; Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
  • Aragaki AK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Butterbach K; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Caan BJ; Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.
  • Carlson CS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Chanock SJ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
  • Curtis KR; Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA.
  • Fuchs CS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Gala M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.
  • Giovannucci EL; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Gogarten SM; Department of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA.
  • Hayes RB; Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA.
  • Henderson B; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Hunter DJ; Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Jackson RD; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
  • Kolonel LN; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  • Kooperberg C; Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.
  • Küry S; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • LaCroix A; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Laurie CC; Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA.
  • Laurie CA; Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA.
  • Lemire M; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Levine D; Service de Génétique Médicale, CHU Nantes, Nantes 44093, France.
  • Ma J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
  • Makar KW; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  • Qu C; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  • Taverna D; Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Ulrich CM; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  • Wu K; Harvard School of Public Health, Boston, Massachusetts 02114, USA.
  • Kono S; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Nat Commun ; 6: 7138, 2015 Jul 07.
Article en En | MEDLINE | ID: mdl-26151821
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos