Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.
J Med Genet
; 53(1): 15-23, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26187060
ABSTRACT
Approximately 5%-10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations. Some mutations are unique to one family and others are recurrent; the spectrum of BRCA1/BRCA2 mutations varies depending on the geographical origins, populations or ethnic groups. In this review, we compiled data from 11 participating Asian countries (Bangladesh, Mainland China, Hong Kong SAR, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Thailand and Vietnam), and from ethnic Asians residing in Canada and the USA. We have additionally conducted a literature review to include other Asian countries mainly in Central and Western Asia. We present the current pathogenic mutation spectrum of BRCA1/BRCA2 genes in patients with breast cancer in various Asian populations. Understanding BRCA1/BRCA2 mutations in Asians will help provide better risk assessment and clinical management of breast cancer.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Mutación de Línea Germinal
/
Genes BRCA1
/
Predisposición Genética a la Enfermedad
/
Genes BRCA2
/
Mutación
Tipo de estudio:
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Med Genet
Año:
2016
Tipo del documento:
Article