Antioxidant potential of CORM-A1 and resveratrol during TNF-&#945;/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells.

Babu, Dinesh; Leclercq, Georges; Goossens, Vera; Remijsen, Quinten; Vandenabeele, Peter; Motterlini, Roberto; Lefebvre, Romain A

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells.

Babu, Dinesh; Leclercq, Georges; Goossens, Vera; Remijsen, Quinten; Vandenabeele, Peter; Motterlini, Roberto; Lefebvre, Romain A.

Afiliación

Babu D; Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences, Ghent University, Belgium. Electronic address: dinesh.babu@ugent.be.
Leclercq G; Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
Goossens V; Inflammation Research Center, Molecular Signaling and Cell Death Unit, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Molecular Signaling and Cell Death Unit, Ghent University, Ghent, Belgium.
Remijsen Q; Inflammation Research Center, Molecular Signaling and Cell Death Unit, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Molecular Signaling and Cell Death Unit, Ghent University, Ghent, Belgium.
Vandenabeele P; Inflammation Research Center, Molecular Signaling and Cell Death Unit, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Molecular Signaling and Cell Death Unit, Ghent University, Ghent, Belgium.
Motterlini R; Inserm U955, Equipe 12 and University Paris-Est Créteil, Faculty of Medicine, F-94000 Créteil, France.
Lefebvre RA; Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.

Toxicol Appl Pharmacol ; 288(2): 161-78, 2015 Oct 15.

Article en En | MEDLINE | ID: mdl-26187750

Asunto(s)

Antiinflamatorios/farmacología; Antioxidantes/farmacología; Apoptosis/efectos de los fármacos; Boranos/farmacología; Carbonatos/farmacología; Cicloheximida/toxicidad; Células Epiteliales/efectos de los fármacos; Mucosa Intestinal/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; Estilbenos/farmacología; Factor de Necrosis Tumoral alfa/toxicidad; Animales; Línea Celular; Citoprotección; Células Epiteliales/inmunología; Células Epiteliales/metabolismo; Células Epiteliales/patología; Mucosa Intestinal/inmunología; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patología; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Ratones; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; NADPH Oxidasas/metabolismo; Consumo de Oxígeno/efectos de los fármacos; Resveratrol; Superóxidos/metabolismo

Palabras clave

CORM-A1; Intestinal epithelial cells; Mitochondria; NADPH oxidase; Resveratrol; TNF-α/CHX

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estilbenos / Boranos / Carbonatos / Factor de Necrosis Tumoral alfa / Apoptosis / Estrés Oxidativo / Cicloheximida / Células Epiteliales / Mucosa Intestinal / Antiinflamatorios Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2015 Tipo del documento: Article

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