Comparative Effects of Dexmedetomidine and Propofol on US-Guided Radiofrequency Ablation of Hepatic Neoplasm Under Monitored Anesthesia Care: A Randomized Controlled Study.
Medicine (Baltimore)
; 94(32): e1349, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26266387
ABSTRACT
Percutaneous radiofrequency ablation (RFA) is a useful and safe procedure for treating hepatic neoplasm. However, liver RFA causes severe pain, which thereby increases the demand for monitored anesthesia care (MAC). Here, we compared the efficacy and safety of propofol and dexmedetomidine, which are commonly administered during MAC when performing RFA to assess hepatic neoplasm.In this randomized controlled trial, 40 patients were randomly allocated to 2 groups for elective RFA. Patients received either dexmedetomidine (group D) or propofol (group P). Both groups received the continuous infusion of remifentanil for pain control. The primary outcomes were opioid consumption and differences in partial pressure of arterial carbon dioxide (PaCO2) between pre- and postprocedure RFA. In addition, hemodynamic parameters, patient satisfaction, and interventional radiologist satisfaction were determined.There were significant differences in opioid consumption (50.1â±â16.8âng/kg/min [group D] vs 71.2â±â18.7âng/kg/min [group P]; Pâ=â0.001) and delta PaCO2 (10.4â±â6.4âmm Hg vs 17.2â±â9.2âmm Hg, respectively; Pâ=â0.016). Moreover, respiratory rates were significantly different between groups during RFA (Pâ<â0.001). However, blood pressure and heart rate did not significantly change during RFA. Neither patient nor interventional radiologist satisfaction was significantly different between groups.Dexmedetomidine provides better respiratory stability and reduces opioid consumption in comparison with propofol when administered under MAC when performing RFA for hepatic neoplasm.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Propofol
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Ablación por Catéter
/
Dexmedetomidina
/
Analgésicos
/
Neoplasias Hepáticas
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2015
Tipo del documento:
Article