Digestive cancers and occupational asbestos exposure: incidence study in a cohort of asbestos plant workers.
Occup Environ Med
; 72(11): 792-7, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26304776
ABSTRACT
OBJECTIVE:
The aim of our study was to estimate the incidence of digestive cancers within a cohort of asbestos-exposed workers.METHODS:
Our study was based on a cohort of 2024 participants occupationally exposed to asbestos. The incidence of digestive cancers was calculated from 1 January 1978 to 31 December 2009 and compared with levels among the local general population using Standardised Incidence Ratios (SIRs). Asbestos exposure was assessed using the company's job-exposure matrix.RESULTS:
119 cases of digestive cancer were observed within our cohort, for an expected number of 77 (SIR=1.54 (1.28 to 1.85)). A significantly elevated incidence was observed for peritoneal mesothelioma, particularly in women. Significantly elevated incidences were also observed among men for all digestive cancers, even when excluding peritoneal mesothelioma (SIR=1.50 (1.23 to 1.82)), oesophageal cancer (SIR=1.67 (1.08 to 2.47)) and liver cancer (SIR=1.85 (1.09 to 2.92)). Concerning colorectal cancer, a significant excess of risk was observed for men with exposure duration above 25â years (SIR=1.75 (1.05 to 2.73)).CONCLUSIONS:
Our results are in favour of a link between long-duration asbestos exposure and colorectal cancer in men. They also suggest a relationship between asbestos exposure and cancer of the oesophagus in men. Finally, our results suggest a possible association with small intestine and liver cancers in men.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Exposición Profesional
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Sistema Digestivo
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Neoplasias del Sistema Digestivo
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Neoplasias Intestinales
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Neoplasias Pulmonares
/
Mesotelioma
/
Enfermedades Profesionales
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Occup Environ Med
Asunto de la revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia