Airway Surface Dehydration by Transforming Growth Factor ß (TGF-ß) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone.

Manzanares, Dahis; Krick, Stefanie; Baumlin, Nathalie; Dennis, John S; Tyrrell, Jean; Tarran, Robert; Salathe, Matthias

Manzanares, Dahis; Krick, Stefanie; Baumlin, Nathalie; Dennis, John S; Tyrrell, Jean; Tarran, Robert; Salathe, Matthias.

Afiliación

Manzanares D; From the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami, Miami, Florida 33136 and.
Krick S; From the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami, Miami, Florida 33136 and.
Baumlin N; From the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami, Miami, Florida 33136 and.
Dennis JS; From the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami, Miami, Florida 33136 and.
Tyrrell J; Cystic Fibrosis Center, University of North Carolina, Chapel Hill, North Carolina 27599.
Tarran R; Cystic Fibrosis Center, University of North Carolina, Chapel Hill, North Carolina 27599.
Salathe M; From the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami, Miami, Florida 33136 and msalathe@med.miami.edu.

J Biol Chem ; 290(42): 25710-6, 2015 Oct 16.

Article en En | MEDLINE | ID: mdl-26338706

Asunto(s)

Bronquios/patología; Fibrosis Quística/metabolismo; Canales de Potasio con Entrada de Voltaje/fisiología; Piridonas/farmacología; Factor de Crecimiento Transformador beta1/fisiología; Adenosina Trifosfato/metabolismo; Bronquios/efectos de los fármacos; Fibrosis Quística/tratamiento farmacológico; Fibrosis Quística/patología; Técnicas de Silenciamiento del Gen; Humanos; Depuración Mucociliar/efectos de los fármacos; Proteínas de Neoplasias/genética; Piridonas/uso terapéutico; Factor de Crecimiento Transformador beta1/antagonistas & inhibidores

Palabras clave

BK; LRRC26; airway surface liquid; cilia; cystic fibrosis; epithelium; mallotoxin; pirfenidone; potassium channel; transforming growth factor beta (TGF-B)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Bronquios / Fibrosis Quística / Canales de Potasio con Entrada de Voltaje / Factor de Crecimiento Transformador beta1 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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