Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance.
J Pediatr Endocrinol Metab
; 29(2): 179-84, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26360496
ABSTRACT
BACKGROUND:
Urinary myo-inositol (UMI) level is elevated in adult diabetic patients, and also increases after glucose loading. However, the relationship between UMI and plasma glucose levels in children is unknown. We aimed to assess whether UMI is a practical marker for glucose intolerance in children or not.METHODS:
In Study 1 (328 schoolchildren), fasting and postprandial UMI were measured, with ΔUMI defined as the difference between fasting and postprandial UMI levels. In Study 2, oral glucose tolerance tests and UMI measurements were conducted in 18 children with suspected having diabetes.RESULTS:
For Study 1, ΔUMI was observed [-0.65 (-3.9, 1.35) mg/g creatinine]. For Study 2, children with diabetes or impaired glucose tolerance had a significantly higher ΔUMI than children with normal glucose tolerance.CONCLUSIONS:
These studies demonstrated the normal range of UMI in children and possibility of a novel biomarker for early detection of glucose intolerance in children.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Prueba de Tolerancia a la Glucosa
/
Inositol
Tipo de estudio:
Screening_studies
Límite:
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2016
Tipo del documento:
Article