Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III.
Headache
; 56(3): 479-90, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26364805
ABSTRACT
Vagus nerve stimulation (VNS) is currently undergoing multiple trials to explore its potential for various clinical disorders. To date, VNS has been approved for the treatment of refractory epilepsy and depression. It exerts antiepileptic or antiepileptogenic effect possibly through neuromodulation of certain monoamine pathways. Beyond epilepsy, VNS is also under investigation for the treatment of inflammation, asthma, and pain. VNS influences the production of inflammatory cytokines to dampen the inflammatory response. It triggers the systemic release of catecholamines that alleviates the asthma attack. VNS induces antinociception by modulating multiple pain-associated structures in the brain and spinal cord affecting peripheral/central nociception, opioid response, inflammation process, autonomic activity, and pain-related behavior. Progression in VNS clinical efficacy over time suggests an underlying disease-modifying neuromodulation, which is an emerging field in neurology. With multiple potential clinical applications, further development of VNS is encouraging.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nervio Vago
/
Estimulación del Nervio Vago
Límite:
Humans
Idioma:
En
Revista:
Headache
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos