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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Kung, Daniel W; Griffith, David A; Esler, William P; Vajdos, Felix F; Mathiowetz, Alan M; Doran, Shawn D; Amor, Paul A; Bagley, Scott W; Banks, Tereece; Cabral, Shawn; Ford, Kristen; Garcia-Irizarry, Carmen N; Landis, Margaret S; Loomis, Kathrine; McPherson, Kirk; Niosi, Mark; Rockwell, Kristin L; Rose, Colin; Smith, Aaron C; Southers, James A; Tapley, Susan; Tu, Meihua; Valentine, James J.
Afiliación
  • Kung DW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States. Electronic address: daniel.w.kung@pfizer.com.
  • Griffith DA; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States. Electronic address: david.a.griffith@pfizer.com.
  • Esler WP; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States.
  • Vajdos FF; Structural Biology, Groton, CT 06340, United States.
  • Mathiowetz AM; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States.
  • Doran SD; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States.
  • Amor PA; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Cambridge, MA 02139, United States.
  • Bagley SW; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Banks T; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Cabral S; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Ford K; Primary Pharmacology Group, Groton, CT 06340, United States.
  • Garcia-Irizarry CN; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Landis MS; Pharmaceutical Sciences Research Formulations, Pfizer Worldwide Research and Development, Cambridge, MA 02139, United States.
  • Loomis K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.
  • McPherson K; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.
  • Niosi M; Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, United States.
  • Rockwell KL; Primary Pharmacology Group, Groton, CT 06340, United States.
  • Rose C; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Smith AC; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Southers JA; Worldwide Medicinal Chemistry, Groton, CT 06340, United States.
  • Tapley S; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Groton, CT 06340, United States.
  • Tu M; Worldwide Medicinal Chemistry, Cambridge, MA 02139, United States.
  • Valentine JJ; Primary Pharmacology Group, Groton, CT 06340, United States.
Bioorg Med Chem Lett ; 25(22): 5352-6, 2015 Nov 15.
Article en En | MEDLINE | ID: mdl-26411795
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Acetilcoenzima A / Compuestos de Espiro / Hepatocitos / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Acetilcoenzima A / Compuestos de Espiro / Hepatocitos / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article