Repair Pathway Choices and Consequences at the Double-Strand Break.
Trends Cell Biol
; 26(1): 52-64, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26437586
ABSTRACT
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transformation due to chromosomal translocations. Typically, cells employ two main mechanisms to repair DSBs homologous recombination (HR) and classical nonhomologous end joining (C-NHEJ). In addition, alternative error-prone DSB repair pathways, namely alternative end joining (alt-EJ) and single-strand annealing (SSA), have been recently shown to operate in many different conditions and to contribute to genome rearrangements and oncogenic transformation. Here, we review the mechanisms regulating DSB repair pathway choice, together with the potential interconnections between HR and the annealing-dependent error-prone DSB repair pathways.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reparación del ADN
/
Roturas del ADN de Doble Cadena
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos