Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.

Oetting, W S; Schladt, D P; Guan, W; Miller, M B; Remmel, R P; Dorr, C; Sanghavi, K; Mannon, R B; Herrera, B; Matas, A J; Salomon, D R; Kwok, P-Y; Keating, B J; Israni, A K; Jacobson, P A

Oetting, W S; Schladt, D P; Guan, W; Miller, M B; Remmel, R P; Dorr, C; Sanghavi, K; Mannon, R B; Herrera, B; Matas, A J; Salomon, D R; Kwok, P-Y; Keating, B J; Israni, A K; Jacobson, P A.

Afiliación

Oetting WS; University of Minnesota, Experimental and Clinical Pharmacology, Minneapolis, MN.
Schladt DP; Minneapolis Medical Research Foundation, Minneapolis, MN.
Guan W; University of Minnesota, Department of Biostatistics, Minneapolis, MN.
Miller MB; University of Minnesota, Experimental and Clinical Pharmacology, Minneapolis, MN.
Remmel RP; University of Minnesota, Experimental and Clinical Pharmacology, Minneapolis, MN.
Dorr C; Minneapolis Medical Research Foundation, Minneapolis, MN.
Sanghavi K; University of Minnesota, Experimental and Clinical Pharmacology, Minneapolis, MN.
Mannon RB; University of Alabama, Division of Nephrology, Birmingham, AL.
Herrera B; University of California, San Francisco, CA.
Matas AJ; University of Minnesota, Department of Surgery, Minneapolis, MN.
Salomon DR; The Scripps Research Institute, La Jolla, CA.
Kwok PY; University of California, San Francisco, CA.
Keating BJ; Children's Hospital of Philadelphia, Philadelphia, PA.
Israni AK; Minneapolis Medical Research Foundation, Minneapolis, MN.
Jacobson PA; University of Minnesota, Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.

Am J Transplant ; 16(2): 574-82, 2016 Feb.

Article en En | MEDLINE | ID: mdl-26485092

Asunto(s)

Negro o Afroamericano/genética; Citocromo P-450 CYP3A/genética; Estudio de Asociación del Genoma Completo; Rechazo de Injerto/genética; Polimorfismo de Nucleótido Simple/genética; Complicaciones Posoperatorias/genética; Tacrolimus/uso terapéutico; Adolescente; Adulto; Anciano; Anciano de 80 o más Años; Alelos; Niño; Preescolar; Femenino; Estudios de Seguimiento; Genotipo; Tasa de Filtración Glomerular; Rechazo de Injerto/tratamiento farmacológico; Rechazo de Injerto/etnología; Supervivencia de Injerto; Humanos; Inmunosupresores/uso terapéutico; Lactante; Recién Nacido; Fallo Renal Crónico/genética; Fallo Renal Crónico/cirugía; Pruebas de Función Renal; Trasplante de Riñón/efectos adversos; Masculino; Persona de Mediana Edad; Pronóstico; Factores de Riesgo; Donantes de Tejidos; Receptores de Trasplantes; Población Blanca/genética; Adulto Joven

Palabras clave

basic (laboratory) research/science; genetics; genomics; immunosuppressant; calcineurin inhibitor: tacrolimus; immunosuppression/immune modulation; microarray/gene array; molecular biology: DNA; molecular biology: single polynucleotide polymorphism

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Negro o Afroamericano / Tacrolimus / Polimorfismo de Nucleótido Simple / Citocromo P-450 CYP3A / Estudio de Asociación del Genoma Completo / Rechazo de Injerto Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2016 Tipo del documento: Article País de afiliación: Mongolia

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