Alkaloids with Different Carbon Units from Myrioneuron faberi.
J Nat Prod
; 78(11): 2609-16, 2015 Nov 25.
Article
en En
| MEDLINE
| ID: mdl-26551513
ABSTRACT
Three new Myrioneuron alkaloids, myrifamines A-C (1-3), with unique skeletons were isolated from Myrioneuron faberi. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis, and the stereochemistry of the other two alkaloids was determined using a combination of ROESY experiments and calculated and experimental electronic circular dichroism spectra. Myrifamine C (3) is the first example of a symmetric dimer among the Myrioneuron alkaloids. Known alkaloids myrionamide (4) and schoberine (5) were also isolated, and experimental NMR and X-ray diffraction data suggest their structural revision. Compound 2 showed significant inhibitory activity toward the hepatitis C virus in vitro, with a therapeutic index (CC50/EC50) greater than 108.7.
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1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
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Rubiaceae
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Alcaloides
Idioma:
En
Revista:
J Nat Prod
Año:
2015
Tipo del documento:
Article