Interferon beta-1a long-term therapy related to pulmonary arterial hypertension in multiple sclerosis patients.
Mult Scler
; 22(11): 1495-1498, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-26564996
ABSTRACT
We report two patients with relapsing remitting multiple sclerosis (RRMS) on interferon (IFN) beta-1a treatment for more than 7 years who developed pulmonary arterial hypertension (PAH). Patient 1 developed severe PAH requiring lung transplantation. Histology showed typical proliferative lesions including plexiform lesions consistent with PAH. Patient 2 ceased IFN beta-1a, and their symptoms stabilised. Both cases highlight IFN beta-1a treatment as a potential risk factor for PAH. PAH needs to be considered as a diagnosis in patients on long-term IFN beta-1a treatment who develop new-onset respiratory symptoms.
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Banco de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Esclerosis Múltiple Recurrente-Remitente
/
Interferón beta-1a
/
Hipertensión Pulmonar
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Australia