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Low Vitamin D Levels Are Associated With an Adverse Clinical Outcome in Febrile Neutropenia.
Gupta, Vineeta; Kumar, Vinod; Singh, Surya K.
Afiliación
  • Gupta V; Departments of *Pediatrics †Endocrinology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Pediatr Hematol Oncol ; 38(3): 202-4, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26583614
AIM: The aim of the study was to evaluate the levels of vitamin D in patients of aplastic anemia presenting with febrile neutropenia and its association with clinically important parameters. MATERIALS AND METHODS: The 25-hydroxy vitamin D (25(OH)D) levels were measured in 35 patients of aplastic anemia with febrile neutropenia in the age group of 4 to 16 years. About 30 healthy children served as controls. Vitamin D deficiency was defined as 25(OH)D<20 ng/mL, insufficiency 20 to 29 ng/mL, and sufficiency≥30 ng/mL. RESULTS: The median age of patients was 9.3 years. The mean 25(OH)D level was 17.71±8.90 ng/mL in patients against 23.67±10.80 ng/mL in the control group (P<0.01). About 65.7% of the patients were 25(OH)D deficient (<20 ng/mL). Only 8.6% had sufficient levels. Older (above 10 y) patients, male children, and those from a rural background and a low socioeconomic status had significantly lower 25(OH)D levels as compared with controls. Low 25(OH)D levels were associated with a longer duration (≥7 d) of febrile neutropenia (17.26±7.19 vs. 20.01±12.12 ng/mL) although the difference was not statistically significant. Two patients who expired had significantly lower 25(OH)D levels (12.85±4.12 ng/mL) compared with those who improved (22.86±6.47 ng/mL, P<0.05). CONCLUSIONS: A high prevalence of vitamin D deficiency was observed in patients with febrile neutropenia. Low levels were associated with an adverse clinical outcome.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Neutropenia Febril Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Neutropenia Febril Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: India