Establishment and Dysfunction of the Blood-Brain Barrier.
Cell
; 163(5): 1064-1078, 2015 Nov 19.
Article
en En
| MEDLINE
| ID: mdl-26590417
ABSTRACT
Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Barrera Hematoencefálica
/
Enfermedades del Sistema Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos