Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

Pilecki, Bartosz; Holm, Anne T; Schlosser, Anders; Moeller, Jesper B; Wohl, Alexander P; Zuk, Alexandra V; Heumüller, Stefanie E; Wallis, Russell; Moestrup, Soren K; Sengle, Gerhard; Holmskov, Uffe; Sorensen, Grith L

Pilecki, Bartosz; Holm, Anne T; Schlosser, Anders; Moeller, Jesper B; Wohl, Alexander P; Zuk, Alexandra V; Heumüller, Stefanie E; Wallis, Russell; Moestrup, Soren K; Sengle, Gerhard; Holmskov, Uffe; Sorensen, Grith L.

Afiliación

Pilecki B; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark.
Holm AT; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark.
Schlosser A; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark.
Moeller JB; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark.
Wohl AP; the Center for Biochemistry, Faculty of Medicine and.
Zuk AV; the Center for Biochemistry, Faculty of Medicine and.
Heumüller SE; the Center for Biochemistry, Faculty of Medicine and the Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.
Wallis R; the Department of Infection, Immunity and Inflammation, and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, United Kingdom, and.
Moestrup SK; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark, the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark.
Sengle G; the Center for Biochemistry, Faculty of Medicine and the Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.
Holmskov U; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark.
Sorensen GL; From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark, glsorensen@health.sdu.dk.

J Biol Chem ; 291(3): 1103-14, 2016 Jan 15.

Article en En | MEDLINE | ID: mdl-26601954

Asunto(s)

Proteínas Portadoras/metabolismo; Desmosina/metabolismo; Tejido Elástico/metabolismo; Proteínas de la Matriz Extracelular/metabolismo; Glicoproteínas/metabolismo; Microfibrillas/metabolismo; Proteínas de Microfilamentos/metabolismo; Modelos Moleculares; Tropoelastina/metabolismo; Sustitución de Aminoácidos; Animales; Proteínas Portadoras/química; Proteínas Portadoras/genética; Proteínas de la Matriz Extracelular/química; Proteínas de la Matriz Extracelular/genética; Fibrilina-1; Fibrilinas; Glicoproteínas/química; Glicoproteínas/genética; Humanos; Ligandos; Masculino; Ratones Endogámicos C57BL; Ratones Mutantes; Proteínas de Microfilamentos/química; Proteínas de Microfilamentos/genética; Mutación; Fragmentos de Péptidos/química; Fragmentos de Péptidos/genética; Fragmentos de Péptidos/metabolismo; Dominios y Motivos de Interacción de Proteínas; Isoformas de Proteínas/química; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Multimerización de Proteína; Transporte de Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Tropoelastina/química; Tropoelastina/genética

Palabras clave

analytical ultracentrifugation; calcium-binding protein; elastin; fibrillin; microfibrillar-associated protein 4; site-directed mutagenesis; surface plasmon resonance (SPR)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteínas / Proteínas Portadoras / Modelos Moleculares / Proteínas de la Matriz Extracelular / Tropoelastina / Microfibrillas / Desmosina / Tejido Elástico / Proteínas de Microfilamentos Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca

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