Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen, Su Duy; Maaninka, Katariina; Lappalainen, Jani; Nurmi, Katariina; Metso, Jari; Öörni, Katariina; Navab, Mohamad; Fogelman, Alan M; Jauhiainen, Matti; Lee-Rueckert, Miriam; Kovanen, Petri T

Nguyen, Su Duy; Maaninka, Katariina; Lappalainen, Jani; Nurmi, Katariina; Metso, Jari; Öörni, Katariina; Navab, Mohamad; Fogelman, Alan M; Jauhiainen, Matti; Lee-Rueckert, Miriam; Kovanen, Petri T.

Afiliación

Nguyen SD; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Maaninka K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Lappalainen J; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Nurmi K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Metso J; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Öörni K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Navab M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Fogelman AM; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Jauhiainen M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Lee-Rueckert M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Kovanen PT; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici

Arterioscler Thromb Vasc Biol ; 36(2): 274-84, 2016 Feb.

Article en En | MEDLINE | ID: mdl-26681753

Asunto(s)

Apolipoproteína A-I/metabolismo; Aterosclerosis/enzimología; Quimasas/metabolismo; Células Endoteliales/metabolismo; Inflamación/enzimología; Mastocitos/enzimología; Apolipoproteína A-I/farmacología; Aterosclerosis/inmunología; Aterosclerosis/prevención & control; Adhesión Celular; Línea Celular Tumoral; Colesterol/metabolismo; Técnicas de Cocultivo; Citocinas/metabolismo; Células Endoteliales/efectos de los fármacos; Células Endoteliales/inmunología; Células Espumosas/inmunología; Células Espumosas/metabolismo; Humanos; Inflamación/inmunología; Inflamación/prevención & control; Mediadores de Inflamación/metabolismo; Mastocitos/efectos de los fármacos; Mastocitos/inmunología; FN-kappa B/metabolismo; Activación Neutrófila; Neutrófilos/inmunología; Neutrófilos/metabolismo; Péptidos/farmacología; Estructura Terciaria de Proteína; Proteolisis; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal; Migración Transendotelial y Transepitelial; Molécula 1 de Adhesión Celular Vascular/metabolismo

Palabras clave

apolipoprotein A-I; carboxyl-terminal cleavage; chymase; endothelial cells; inflammatory; mast cell; proteases

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteína A-I / Células Endoteliales / Aterosclerosis / Quimasas / Inflamación / Mastocitos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2016 Tipo del documento: Article

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