Beyond static biomarkers--The dynamic response potential of signaling networks as an alternate biomarker?
Sci Signal
; 8(408): fs21, 2015 Dec 22.
Article
en En
| MEDLINE
| ID: mdl-26696629
ABSTRACT
In this week's issue of Science Signaling, Fey et al. introduce a new type of biomarker. Using the example of neuroblastoma, the authors demonstrate that patient-specific differences in the computed property (the Hill coefficient) of the dynamics of a pathway involved in cell death signaling outperformed the prognostic capability of any single static biomarker alone or in combination.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Transducción de Señal
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Sci Signal
Asunto de la revista:
CIENCIA
/
FISIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos