Multiple amino acid substitutions involved in the adaptation of avian-origin influenza A (H10N7) virus in mice.
Arch Virol
; 161(4): 977-80, 2016 Apr.
Article
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| MEDLINE
| ID: mdl-26699787
ABSTRACT
To identify substitutions that are possibly associated with the adaptation of avian-origin H10N7 virus to mammals, adaptation of the H10N7 virus in mouse lung was carried out by serial lung-to-lung passage. Genomic analysis of the mouse-adapted virus revealed amino acid changes in the PB2 (E627K), PA (T97I), and HA (G409E) proteins, and this virus was more virulent in mice than the wild-type virus. Our results suggest that these substitutions are involved in the enhancement of the replication efficiency of avian-origin H10N7 virus, resulting in severe disease in mice. Continued poultry surveillance of these substitutions in H10N7 viruses is required.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Infecciones por Orthomyxoviridae
Límite:
Animals
Idioma:
En
Revista:
Arch Virol
Año:
2016
Tipo del documento:
Article
País de afiliación:
China