Correlation between antimicrobial resistance and virulence in Klebsiella pneumoniae.
Eur J Clin Microbiol Infect Dis
; 35(3): 333-41, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26718943
ABSTRACT
Klebsiella pneumoniae is responsible for a wide range of infections, including urinary tract infections, pneumonia, bacteremia, and liver abscesses. In addition to susceptible clinical isolates involved in nosocomial infections, multidrug-resistant (MDR) and hypervirulent (hvKP) strains have evolved separately in distinct clonal groups. The rapid geographic spread of these isolates is of particular concern. However, we still know little about the virulence of K. pneumoniae except for hvKP, whose secrets are beginning to be revealed. The treatment of K. pneumoniae infections is threatened by the emergence of antimicrobial resistance. The dissemination of resistance is associated with genetic mobile elements, such as plasmids that may also carry virulence determinants. A proficient pathogen should be virulent, resistant to antibiotics, and epidemic. However, the interplay between resistance and virulence is poorly understood. Here, we review current knowledge on the topic.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Klebsiella
/
Farmacorresistencia Bacteriana
/
Klebsiella pneumoniae
/
Antiinfecciosos
Límite:
Humans
Idioma:
En
Revista:
Eur J Clin Microbiol Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia