Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.
Curr Neurol Neurosci Rep
; 16(2): 17, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26759318
ABSTRACT
Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glioma
Límite:
Humans
Idioma:
En
Revista:
Curr Neurol Neurosci Rep
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos