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Genome-wide association studies based on sequence-derived genotypes reveal new QTL associated with conformation and performance traits in the Franches-Montagnes horse breed.
Frischknecht, M; Signer-Hasler, H; Leeb, T; Rieder, S; Neuditschko, M.
Afiliación
  • Frischknecht M; Agroscope, Swiss National Stud Farm, Les Longs-Prés, 1580, Avenches, Switzerland.
  • Signer-Hasler H; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
  • Leeb T; Swiss Competence Center of Animal Breeding and Genetics, University of Bern, Bern University of Applied Sciences HAFL & Agroscope, Bremgartenstrasse 109a, 3001, Bern, Switzerland.
  • Rieder S; Swiss Competence Center of Animal Breeding and Genetics, University of Bern, Bern University of Applied Sciences HAFL & Agroscope, Bremgartenstrasse 109a, 3001, Bern, Switzerland.
  • Neuditschko M; Bern University of Applied Sciences, School of Agricultural, Forest and Food Sciences, Länggasse, 85 3052, Zollikofen, Switzerland.
Anim Genet ; 47(2): 227-9, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26767322
ABSTRACT
To identify novel quantitative trait loci (QTL) within horses, we performed genome-wide association studies (GWAS) based on sequence-level genotypes for conformation and performance traits in the Franches-Montagnes (FM) horse breed. Sequence-level genotypes of FM horses were derived by re-sequencing 30 key founders and imputing 50K data of genotyped horses. In total, we included 1077 FM horses genotyped for ~4 million SNPs and their respective de-regressed breeding values of the traits in the analysis. Based on this dataset, we identified a total of 14 QTL associated with 18 conformation traits and one performance trait. Therefore, our results suggest that the application of sequence-derived genotypes increases the power to identify novel QTL which were not identified previously based on 50K SNP chip data.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cruzamiento / Sitios de Carácter Cuantitativo / Caballos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Anim Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2016 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cruzamiento / Sitios de Carácter Cuantitativo / Caballos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Anim Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2016 Tipo del documento: Article País de afiliación: Suiza