Thrombin-Responsive Gated Silica Mesoporous Nanoparticles As Coagulation Regulators.
Langmuir
; 32(5): 1195-200, 2016 Feb 09.
Article
en En
| MEDLINE
| ID: mdl-26794474
ABSTRACT
The possibility of achieving sophisticated actions in complex biological environments using gated nanoparticles is an exciting prospect with much potential. We herein describe new gated mesoporous silica nanoparticles (MSN) loaded with an anticoagulant drug and capped with a peptide containing a thrombin-specific cleavage site. When the coagulation cascade was triggered, active thrombin degraded the capping peptidic sequence and induced the release of anticoagulant drugs to delay the clotting process. The thrombin-dependent response was assessed and a significant increase in coagulation time in plasma from 2.6 min to 5 min was found. This work broadens the application of gated silica nanoparticles and demonstrates their ability to act as controllers in a complex scenario such as hemostasis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombina
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Dióxido de Silicio
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Nanopartículas
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Acenocumarol
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Anticoagulantes
Límite:
Animals
Idioma:
En
Revista:
Langmuir
Asunto de la revista:
QUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
India