Streptozotocin-induced diabetes, and the optic nerve blood barrier.
Arch Soc Esp Oftalmol
; 91(4): 170-6, 2016 Apr.
Article
en En, Es
| MEDLINE
| ID: mdl-26832629
ABSTRACT
OBJECTIVE:
To study the features of the endoneurial micro-vessels of the optic nerve in streptozotocin-induced diabetic animals.METHODS:
Optic nerves from control and streptozotocin-induced diabetic animals were studied by light and transmission electron microscopy. Patency was determined by indirect immunofluorescence albumin detection. The expression of major histocompatibility complex class II molecules was performed by direct immunofluorescence. The endoneurial vessels were counted, and the endothelial cell, the basement membrane, and the surface of the transverse section of the nerve were measured.RESULTS:
Vessels of diabetic rats showed vessel wall thickening, preservation of pericytes, an increase in endothelial cell transcytosis, and an increased number of perivascular macrophage cells. It may be concluded that the effects of hyperglycaemia on the inner vessels of the optic nerve are more similar to the cerebral diabetic vessels than to the retinal vessels in diabetic animals.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nervio Óptico
/
Diabetes Mellitus Experimental
Límite:
Animals
Idioma:
En
/
Es
Revista:
Arch Soc Esp Oftalmol
Año:
2016
Tipo del documento:
Article