Sex differences in the gut microbiome-brain axis across the lifespan.
Philos Trans R Soc Lond B Biol Sci
; 371(1688): 20150122, 2016 Feb 19.
Article
en En
| MEDLINE
| ID: mdl-26833840
ABSTRACT
In recent years, the bidirectional communication between the gut microbiome and the brain has emerged as a factor that influences immunity, metabolism, neurodevelopment and behaviour. Cross-talk between the gut and brain begins early in life immediately following the transition from a sterile in utero environment to one that is exposed to a changing and complex microbial milieu over a lifetime. Once established, communication between the gut and brain integrates information from the autonomic and enteric nervous systems, neuroendocrine and neuroimmune signals, and peripheral immune and metabolic signals. Importantly, the composition and functional potential of the gut microbiome undergoes many transitions that parallel dynamic periods of brain development and maturation for which distinct sex differences have been identified. Here, we discuss the sexually dimorphic development, maturation and maintenance of the gut microbiome-brain axis, and the sex differences therein important in disease risk and resilience throughout the lifespan.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Tracto Gastrointestinal
/
Mamíferos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos