Active paraplegics are protected against exercise-induced oxidative damage through the induction of antioxidant enzymes.
Spinal Cord
; 54(10): 830-837, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-26882488
ABSTRACT
STUDY DESIGN:
Experimental study.OBJECTIVES:
Exercise improves functional capacity in spinal cord injury (SCI). However, exhaustive exercise, especially when sporadic, is linked to the production of reactive oxygen species that may have a detrimental effect on SCI. We aimed to study the effect of a single bout of exhaustive exercise on systemic oxidative stress parameters and on the expression of antioxidant enzymes in individuals with paraplegia.SETTING:
The study was conducted in the Physical Therapy department and the Physical Education and Sports department of the University of Valencia.METHODS:
Sixteen paraplegic subjects were submitted to a graded exercise test (GET) until volitional exhaustion. They were divided into active or non-active groups. Blood samples were drawn immediately, 1 and 2 h after the GET. We determined plasma malondialdehyde (MDA) and protein carbonylation as markers of oxidative damage. Antioxidant gene expression (catalase and glutathione peroxidase-GPx) was determined in peripheral blood mononuclear cells.RESULTS:
We found a significant increase in plasma MDA and protein carbonyls immediately after the GET (P<0.05). This increment correlated significantly with the lactate levels. Active paraplegics showed lower levels of exercise-induced oxidative damage (P<0.05) and higher exercise-induced catalase (P<0.01) and GPx (P<0.05) gene expression after the GET.CONCLUSIONS:
These results suggest that exercise training may be useful in SCI patients to develop systemic antioxidant defenses that may protect them against exercise-induced oxidative damage.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Paraplejía
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Ejercicio Físico
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Regulación de la Expresión Génica
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Antioxidantes
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Spinal Cord
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
España