The effect of surgery (Ovariohysterectomy) on the plasma disposition of meloxicam following intravenous administration in dogs.
BMC Vet Res
; 12: 33, 2016 Feb 20.
Article
en En
| MEDLINE
| ID: mdl-26896943
ABSTRACT
BACKGROUND:
Meloxicam (MLX) is a nonsteroidal anti-inflammatory drug used in the relief of postoperative pain for human and veterinary medicine. This study was designed to investigate the effect of surgery on the plasma disposition of MLX in dogs undergoing ovariohysterectomy following a single intravenous injection at a dose of 0.2 mg/kg bodyweight. Eight crossbred bitches were used in the study. A two-phase experimental design with a 10-day washout period was used. Pre-operative MLX was administered intravenously to 8 bitches about 10 days before surgery (Phase I, control) at a dose of 0.2 mg/kg bodyweight and peri-operative MLX was administered intravenously after anaesthesia and 15 min before the start of surgery (Phase II). Blood samples were collected from all animals at various times between 1 and 96 h after the drug administrations in both phases. The drug concentrations were analysed using high performance liquid chromatography.RESULTS:
The volume of plasma MLX distribution at steady-state (Vdss) of the control group (Vdss 263.0 ml/kg) was significantly greater (P < 0.05) compared to that of the surgery group (Vdss 149.3 ml/kg). The AUC values were higher (29.5 vs. 23.0 µg.h(2)/ml) and the CL values were lower (7.7 vs. 10.5 ml.h/kg) in the surgery group compared to the control group, respectively, but differences were not significant.CONCLUSIONS:
The results of the present study indicated that surgery could alter the plasma disposition of MLX and thus the drug efficacy and side effects such as gastrointestinal ulceration, unusual bleeding and loss of kidney function/failure when repeated doses are used.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tiazinas
/
Tiazoles
/
Ovariectomía
/
Antiinflamatorios no Esteroideos
/
Perros
/
Histerectomía
Límite:
Animals
Idioma:
En
Revista:
BMC Vet Res
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Turquía