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Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
Hansen, Steffen V F; Christiansen, Elisabeth; Urban, Christian; Hudson, Brian D; Stocker, Claire J; Due-Hansen, Maria E; Wargent, Ed T; Shimpukade, Bharat; Almeida, Reinaldo; Ejsing, Christer S; Cawthorne, Michael A; Kassack, Matthias U; Milligan, Graeme; Ulven, Trond.
Afiliación
  • Hansen SV; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Christiansen E; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Urban C; Institute of Pharmaceutical and Medicinal Chemistry, University of Düsseldorf , Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
  • Hudson BD; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow G12 8QQ, Scotland, U.K.
  • Stocker CJ; Clore Laboratory, University of Buckingham , Hunter Street, Buckingham MK18 1EG, U.K.
  • Due-Hansen ME; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Wargent ET; Clore Laboratory, University of Buckingham , Hunter Street, Buckingham MK18 1EG, U.K.
  • Shimpukade B; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Almeida R; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Ejsing CS; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
  • Cawthorne MA; Clore Laboratory, University of Buckingham , Hunter Street, Buckingham MK18 1EG, U.K.
  • Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, University of Düsseldorf , Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
  • Milligan G; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow G12 8QQ, Scotland, U.K.
  • Ulven T; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark , Campusvej 55, DK-5230 Odense M, Denmark.
J Med Chem ; 59(6): 2841-6, 2016 Mar 24.
Article en En | MEDLINE | ID: mdl-26928019
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenilpropionatos / Receptores Acoplados a Proteínas G / Hipoglucemiantes Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenilpropionatos / Receptores Acoplados a Proteínas G / Hipoglucemiantes Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca