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Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.
Rennert, Robert C; Achrol, Achal S; Januszyk, Michael; Kahn, Suzana A; Liu, Tiffany T; Liu, Yi; Sahoo, Debashis; Rodrigues, Melanie; Maan, Zeshaan N; Wong, Victor W; Cheshier, Samuel H; Chang, Steven D; Steinberg, Gary K; Harsh, Griffith R; Gurtner, Geoffrey C.
Afiliación
  • Rennert RC; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Achrol AS; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
  • Januszyk M; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Kahn SA; Stanford Center for Biomedical Informatics, Stanford University, Stanford, California, USA.
  • Liu TT; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
  • Liu Y; Stanford Center for Biomedical Informatics, Stanford University, Stanford, California, USA.
  • Sahoo D; Stanford Center for Biomedical Informatics, Stanford University, Stanford, California, USA.
  • Rodrigues M; Stanford Center for Biomedical Informatics, Stanford University, Stanford, California, USA.
  • Maan ZN; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Wong VW; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Cheshier SH; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Chang SD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
  • Steinberg GK; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
  • Harsh GR; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
  • Gurtner GC; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Stem Cells ; 34(6): 1702-7, 2016 06.
Article en En | MEDLINE | ID: mdl-26991945
ABSTRACT
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;341702-1707.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Encefálicas / Glioblastoma Límite: Humans Idioma: En Revista: Stem Cells Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Encefálicas / Glioblastoma Límite: Humans Idioma: En Revista: Stem Cells Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos