Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14.

Zou, Haiyin; Wu, Ying; Brew, Keith

Zou, Haiyin; Wu, Ying; Brew, Keith.

Afiliación

Zou H; From the Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Wu Y; From the Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431.
Brew K; From the Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida 33431 kbrew@fau.edu.

J Biol Chem ; 291(21): 11348-58, 2016 May 20.

Article en En | MEDLINE | ID: mdl-27033700

Asunto(s)

Metaloproteinasa 14 de la Matriz/química; Metaloproteinasa 14 de la Matriz/metabolismo; Metaloproteinasa 1 de la Matriz/química; Metaloproteinasa 1 de la Matriz/metabolismo; Metaloproteinasa 3 de la Matriz/química; Metaloproteinasa 3 de la Matriz/metabolismo; Inhibidor Tisular de Metaloproteinasa-1/química; Inhibidor Tisular de Metaloproteinasa-1/metabolismo; Inhibidor Tisular de Metaloproteinasa-2/química; Inhibidor Tisular de Metaloproteinasa-2/metabolismo; Humanos; Metaloproteinasa 1 de la Matriz/genética; Metaloproteinasa 14 de la Matriz/genética; Metaloproteinasa 3 de la Matriz/genética; Modelos Moleculares; Mutagénesis Sitio-Dirigida; Dominios y Motivos de Interacción de Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Termodinámica; Inhibidor Tisular de Metaloproteinasa-1/genética; Inhibidor Tisular de Metaloproteinasa-2/genética

Palabras clave

calorimetry; conformational change; enzyme inhibitor; matrix metalloproteinase (MMP); protein dynamic; protein engineering; protein-protein interaction; thermodynamics; tissue inhibitor of metalloproteinase (TIMP); zinc

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metaloproteinasa 3 de la Matriz / Inhibidor Tisular de Metaloproteinasa-1 / Inhibidor Tisular de Metaloproteinasa-2 / Metaloproteinasa 1 de la Matriz / Metaloproteinasa 14 de la Matriz Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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