Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity.
Arch Pharm (Weinheim)
; 349(5): 309-26, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-27062086
ABSTRACT
Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Quinoxalinas
/
Proteínas Tirosina Quinasas
/
Inhibidores de Proteínas Quinasas
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Año:
2016
Tipo del documento:
Article
País de afiliación:
Egipto