Identifying gene expression modules that define human cell fates.
Stem Cell Res
; 16(3): 712-24, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-27108395
ABSTRACT
Using a compendium of cell-state-specific gene expression data, we identified genes that uniquely define cell states, including those thought to represent various developmental stages. Our analysis sheds light on human cell fate through the identification of core genes that are altered over several developmental milestones, and across regional specification. Here we present cell-type specific gene expression data for 17 distinct cell states and demonstrate that these modules of genes can in fact define cell fate. Lastly, we introduce a web-based database to disseminate the results.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Stem Cell Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos