Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS.

Chang, Qing; Martin, Lee J

Chang, Qing; Martin, Lee J.

Afiliación

Chang Q; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, MD 21205, United States. Electronic address: qchang1@jhmi.edu.
Martin LJ; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, MD 21205, United States; Department of Neuroscience, Johns Hopkins University School of Medicine, MD 21205, United States.

Neurobiol Dis ; 93: 78-95, 2016 09.

Article en En | MEDLINE | ID: mdl-27151771

Asunto(s)

Esclerosis Amiotrófica Lateral/metabolismo; Canales de Calcio/metabolismo; Calcio/metabolismo; Neuronas Motoras/metabolismo; Médula Espinal/metabolismo; Esclerosis Amiotrófica Lateral/patología; Animales; Modelos Animales de Enfermedad; Ácido Glutámico/metabolismo; Ratones Transgénicos; Neuronas Motoras/patología; Médula Espinal/patología; Superóxido Dismutasa-1/genética; Superóxido Dismutasa-1/metabolismo

Palabras clave

Calcium channel localization; G93A-SOD1 mice; Persistent Ca(2+) current; Quantitative single-cell RT-PCR; Whole-cell patch-clamp; high voltage activated Ca(2+) currents

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Médula Espinal / Canales de Calcio / Calcio / Esclerosis Amiotrófica Lateral / Neuronas Motoras Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article

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