Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis.
Cancer Invest
; 34(5): 220-30, 2016 May 27.
Article
en En
| MEDLINE
| ID: mdl-27191482
ABSTRACT
Apoptosis plays an important role in prevention of colon cancer. In the present study, different ratios of fish oil and corn oil increased Fas expression in both phases and a decrease in FasL expression only in post initiation phase. Treatment with fish oil activated the intrinsic apoptotic pathway by increasing Bax expression and Cyt c release and decreasing Bcl-2 levels in both phases. This suggests that intrinsic pathway is upregulated by fish oil; however, Fas-FasL activity may be involved in inhibition of reversal of immune surveillance in tumor cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aceites de Pescado
/
Anticarcinógenos
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Apoptosis
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Neoplasias del Colon
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Carcinogénesis
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Cancer Invest
Año:
2016
Tipo del documento:
Article
País de afiliación:
India