Programming Surface Chemistry with Engineered Cells.
ACS Synth Biol
; 5(9): 936-41, 2016 09 16.
Article
en En
| MEDLINE
| ID: mdl-27203116
ABSTRACT
We have developed synthetic gene networks that enable engineered cells to selectively program surface chemistry. E. coli were engineered to upregulate biotin synthase, and therefore biotin synthesis, upon biochemical induction. Additionally, two different functionalized surfaces were developed that utilized binding between biotin and streptavidin to regulate enzyme assembly on programmable surfaces. When combined, the interactions between engineered cells and surfaces demonstrated that synthetic biology can be used to engineer cells that selectively control and modify molecular assembly by exploiting surface chemistry. Our system is highly modular and has the potential to influence fields ranging from tissue engineering to drug development and delivery.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ingeniería Celular
Idioma:
En
Revista:
ACS Synth Biol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos