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[The association of the DRD3 gene with Parkinson's disease].
Ivanova, S A; Alifirova, V M; Zhukova, I A; Boiko, A S; Fedorenko, O Yu; Zhukova, N G; Bokhan, N A.
Afiliación
  • Ivanova SA; Mental Health Research Institute, Tomsk, Russia; National Research Tomsk Polytechnic University,Tomsk, Russia.
  • Alifirova VM; Siberian State Medical Iniversity, Tomsk, Russia.
  • Zhukova IA; Siberian State Medical Iniversity, Tomsk, Russia.
  • Boiko AS; Mental Health Research Institute, Tomsk, Russia.
  • Fedorenko OY; Mental Health Research Institute, Tomsk, Russia; National Research Tomsk Polytechnic University,Tomsk, Russia.
  • Zhukova NG; Siberian State Medical Iniversity, Tomsk, Russia.
  • Bokhan NA; Mental Health Research Institute, Tomsk, Russia; Siberian State Medical Iniversity, Tomsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 116(5): 71-74, 2016.
Article en Ru | MEDLINE | ID: mdl-27240184
OBJECTIVE: To investigate the association between dopamine receptor DRD3 gene tag single nucleotide polymorphisms (SNPs) and the risk of Parkinson's disease (PD). MATERIAL AND METHODS: One hundred and forty-three patients with PD and 96 healthy individuals from the Russian population were examined. Ten tag SNPs (rs963468, rs2134655, rs9817063, rs324035, rs11721264, rs1800828, rs3773678, rs167770, rs167771, rs7633291) within DRD3 have been genotyped. RESULTS AND CONCLUSION: Associations between 4 polymorphisms (rs11721264, rs3773678, rs167771, rs324035) and PD have been found. Our study confirms the involvement of polymorphic features of dopamine receptors genes in the pathophysiology in PD.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Predisposición Genética a la Enfermedad / Receptores de Dopamina D3 Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia / Europa Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Predisposición Genética a la Enfermedad / Receptores de Dopamina D3 Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia / Europa Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Rusia