[IMPACT OF RONCOLEUKIN ON BALANCE OF CYTOKINS IN COMPLEX TREATMENT OF OBTURATION JAUNDICE OF NONTUMORAL GENESIS].
Klin Khir
; (2): 24-7, 2016 Feb.
Article
en Ru
| MEDLINE
| ID: mdl-27244913
ABSTRACT
The results of surgical treatment of 137 patients, suffering obturation jaundice of non-tumoral etiology, were analyzed. In all the patients the cause of obturation jaundice was choledocholithiasis. Roncoleukin was infused intravenously additionally in a complex of therapy. A degree of hepatic dysfunction was determined, taking into account the cholestasis markers. In 23 patients purulent cholangitis have occurred on background of obturation jaundice. Concentration of cytokins TNF-α, IFN-γ, IL-1, IL-2, IL-4, IL-6, IL-10 in sera were determined, using immunoassay analysis. The cytokins dysbalance severity preoperatively and dynamics of its changes have depended upon the hepatic dysbalance degree and presence of purulent cholangitis; a dysbalance is deeper, when the hepatic dysfunction is higher. Application of pathogenetically substantiated purposeful cytokinotherapy, including roncoleukin, have promoted the cytokins dysbalance elimination and improvement of the patients treatment results.
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Banco de datos:
MEDLINE
Asunto principal:
Colangitis
/
Colestasis
/
Interleucina-2
/
Coledocolitiasis
/
Ictericia Obstructiva
/
Factores Inmunológicos
Límite:
Aged80
Idioma:
Ru
Revista:
Klin Khir
Año:
2016
Tipo del documento:
Article