The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.

Sandalova, Tatyana; Lee, Mijoon; Henriques-Normark, Birgitta; Hesek, Dusan; Mobashery, Shahriar; Mellroth, Peter; Achour, Adnane

Sandalova, Tatyana; Lee, Mijoon; Henriques-Normark, Birgitta; Hesek, Dusan; Mobashery, Shahriar; Mellroth, Peter; Achour, Adnane.

Afiliación

Sandalova T; Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, and Department of Infectious Diseases, Karolinska University Hospital, Solna, Stockholm, SE, 17176, Sweden.
Lee M; Departments of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Henriques-Normark B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 171 77, Sweden.
Hesek D; Department of Clinical Microbiology, Karolinska University Hospital, Solna, Stockholm, 17176, Sweden.
Mobashery S; Departments of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Mellroth P; Departments of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Achour A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 171 77, Sweden. peter.mellroth@ki.se.

Mol Microbiol ; 101(6): 954-67, 2016 09.

Article en En | MEDLINE | ID: mdl-27273793

Asunto(s)

N-Acetil Muramoil-L-Alanina Amidasa/química; N-Acetil Muramoil-L-Alanina Amidasa/metabolismo; Peptidoglicano/química; Peptidoglicano/metabolismo; Proteínas Bacterianas/química; Proteínas Bacterianas/metabolismo; Dominio Catalítico; Pared Celular/enzimología; Pared Celular/metabolismo; Cristalografía por Rayos X; Modelos Moleculares; Estructura Terciaria de Proteína; Subunidades de Proteína; Streptococcus pneumoniae/enzimología; Streptococcus pneumoniae/metabolismo; Relación Estructura-Actividad

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Peptidoglicano / N-Acetil Muramoil-L-Alanina Amidasa Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Microbiol Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Suecia

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