Glazed clay pottery and lead exposure in Mexico: Current experimental evidence.
Nutr Neurosci
; 20(9): 513-518, 2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-27297776
ABSTRACT
OBJECTIVES:
Lead exposure remains a significant environmental problem; lead is neurotoxic, especially in developing humans. In Mexico, lead in human blood is still a concern. Historically, much of the lead exposure is attributed to the use of handcrafted clay pottery for cooking, storing and serving food. However, experimental cause-and-effect demonstration is lacking. The present study explores this issue with a prospective experimental approach.METHODS:
We used handcrafted clay containers to prepare and store lemonade, which was supplied as drinking water to pregnant rats throughout the gestational period. RESULTS ANDDISCUSSION:
We found that clay pots, jars, and mugs leached on average 200â µg/l lead, and exposure to the lemonade resulted in 2.5â µg/dl of lead in the pregnant rats' blood. Neonates also showed increased lead content in the hippocampus and cerebellum. Caspase-3 activity was found to be statistically increased in the hippocampus in prenatally exposed neonates, suggesting increased apoptosis in that brain region. Glazed ceramics are still an important source of lead exposure in Mexico, and our results confirm that pregnancy is a vulnerable period for brain development.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Contaminación de Alimentos
/
Utensilios de Comida y Culinaria
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Intoxicación del Sistema Nervioso por Plomo
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Almacenamiento de Alimentos
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Silicatos de Aluminio
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Exposición Dietética
/
Plomo
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Female
/
Humans
/
Male
/
Pregnancy
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Nutr Neurosci
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
NEUROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
México