Interaction between Helicobacter pylori and host genetic variants in gastric carcinogenesis.
Future Oncol
; 12(18): 2127-34, 2016 Sep.
Article
en En
| MEDLINE
| ID: mdl-27324311
ABSTRACT
Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Variación Genética
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Helicobacter pylori
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Infecciones por Helicobacter
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Carcinogénesis
Límite:
Humans
Idioma:
En
Revista:
Future Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
China