Your browser doesn't support javascript.
loading
Lack of effect of ethanol on cocaine prime-induced reinstatement of extinguished cocaine self-administration in rhesus monkeys.
Czoty, Paul W.
Afiliación
  • Czoty PW; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Behav Pharmacol ; 27(7): 633-6, 2016 10.
Article en En | MEDLINE | ID: mdl-27509315
Cocaine and alcohol are commonly co-abused for reasons that are incompletely understood. Laboratory animal studies have suggested that, although the reinforcing effects of low cocaine doses are increased following chronic ethanol (EtOH) consumption, acute EtOH administration does not consistently alter cocaine self-administration. The present study examined whether EtOH influences another abuse-related effect of cocaine: reinstatement of extinguished responding. Rhesus monkeys that had previously consumed EtOH for 8 weeks (2.0 g/kg over 1 h, 5 days/week) self-administered up to 10 injections per day of 0.1 mg/kg cocaine under a fixed-interval 300-s schedule. After responding had been extinguished by substituting saline for cocaine, a pre-session infusion of saline or EtOH (0.5 or 1.0 g/kg, intravenously over 10 min) was followed by a 'priming' injection of saline or cocaine (intravenously). Responding was increased significantly by priming injections of cocaine, but not saline. EtOH infusions neither reinstated behavior when administered before a saline prime nor altered the priming effect of cocaine. The inability of EtOH to alter the response-reinstating ability of cocaine provides further evidence for a lack of acute behavioral interactions between cocaine and EtOH.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Refuerzo en Psicología / Autoadministración / Cocaína / Etanol Límite: Animals Idioma: En Revista: Behav Pharmacol Asunto de la revista: CIENCIAS DO COMPORTAMENTO / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Refuerzo en Psicología / Autoadministración / Cocaína / Etanol Límite: Animals Idioma: En Revista: Behav Pharmacol Asunto de la revista: CIENCIAS DO COMPORTAMENTO / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos