Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro.
J Infect Dis
; 214(9): 1357-1360, 2016 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-27521359
ABSTRACT
Zika virus has emerged in the Americas, where dengue virus is endemic. Among the 4 serotypes of dengue virus, antibody-dependent enhancement is thought to enhance viral replication and disease severity. Reports suggest that anti-dengue virus antibody may enhance Zika virus replication. We investigated whether Zika virus antibodies enhance dengue virus replication, by exposing C57Bl/6 mice to Zika virus. Polyclonal serum was verified for strong Zika virus-neutralizing, dengue virus-subneutralizing capacity. Then we determined the enhancement capabilities of Zika virus-immune serum for dengue virus in vitro. We showed that Zika virus antibodies have the ability to enhance dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.
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Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Acrecentamiento Dependiente de Anticuerpo
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Virus del Dengue
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Virus Zika
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Anticuerpos Antivirales
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Formación de Anticuerpos
Límite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2016
Tipo del documento:
Article