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Structure-based discovery of opioid analgesics with reduced side effects.
Manglik, Aashish; Lin, Henry; Aryal, Dipendra K; McCorvy, John D; Dengler, Daniela; Corder, Gregory; Levit, Anat; Kling, Ralf C; Bernat, Viachaslau; Hübner, Harald; Huang, Xi-Ping; Sassano, Maria F; Giguère, Patrick M; Löber, Stefan; Scherrer, Grégory; Kobilka, Brian K; Gmeiner, Peter; Roth, Bryan L; Shoichet, Brian K.
Afiliación
  • Manglik A; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Lin H; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.
  • Aryal DK; Department of Pharmacology, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, USA.
  • McCorvy JD; Department of Pharmacology, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, USA.
  • Dengler D; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
  • Corder G; Department of Anesthesiology, Perioperative and Pain Medicine, Neurosurgery, Stanford Neurosciences Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Levit A; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.
  • Kling RC; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
  • Bernat V; Institut für Physiologie und Pathophysiologie, Paracelsus Medical University, 90419 Nuremberg, Germany.
  • Hübner H; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
  • Huang XP; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
  • Sassano MF; Department of Pharmacology, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, USA.
  • Giguère PM; Department of Pharmacology, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, USA.
  • Löber S; Department of Pharmacology, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, USA.
  • Da Duan; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
  • Scherrer G; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.
  • Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Gmeiner P; Department of Anesthesiology, Perioperative and Pain Medicine, Neurosurgery, Stanford Neurosciences Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Roth BL; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Shoichet BK; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany.
Nature ; 537(7619): 185-190, 2016 09 08.
Article en En | MEDLINE | ID: mdl-27533032
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiofenos / Urea / Receptores Opioides mu / Descubrimiento de Drogas / Analgésicos Opioides Límite: Animals / Humans / Male Idioma: En Revista: Nature Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiofenos / Urea / Receptores Opioides mu / Descubrimiento de Drogas / Analgésicos Opioides Límite: Animals / Humans / Male Idioma: En Revista: Nature Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos