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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.
Esmail, Hanif; Lai, Rachel P; Lesosky, Maia; Wilkinson, Katalin A; Graham, Christine M; Coussens, Anna K; Oni, Tolu; Warwick, James M; Said-Hartley, Qonita; Koegelenberg, Coenraad F; Walzl, Gerhard; Flynn, JoAnne L; Young, Douglas B; Barry Iii, Clifton E; O'Garra, Anne; Wilkinson, Robert J.
Afiliación
  • Esmail H; Department of Medicine, Imperial College London, London, UK.
  • Lai RP; Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Lesosky M; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Wilkinson KA; Francis Crick Institute Mill Hill Laboratory, London, UK.
  • Graham CM; Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Coussens AK; Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
  • Oni T; Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Warwick JM; Francis Crick Institute Mill Hill Laboratory, London, UK.
  • Said-Hartley Q; Francis Crick Institute Mill Hill Laboratory, London, UK.
  • Koegelenberg CF; Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Walzl G; Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Flynn JL; Department of Medical Imaging and Clinical Oncology, Stellenbosch University, Cape Town, South Africa.
  • Young DB; Department of Radiology, Groote Schuur Hospital, Cape Town, South Africa.
  • Barry Iii CE; Department of Medicine, Stellenbosch University, Cape Town, South Africa.
  • O'Garra A; Department of Medicine, Stellenbosch University, Cape Town, South Africa.
  • Wilkinson RJ; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Nat Med ; 22(10): 1090-1093, 2016 10.
Article en En | MEDLINE | ID: mdl-27595321
ABSTRACT
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Infecciones por VIH / Tuberculosis Latente Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Infecciones por VIH / Tuberculosis Latente Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido