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T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production.
Sumi, Hiroyuki; Inazuka, Masakazu; Hashimoto, Kentaro; Ishikawa, Tomoyasu; Yoshida, Sei; Yabuki, Masato.
Afiliación
  • Sumi H; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: hiroyuki.sumi@takeda.com.
  • Inazuka M; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Hashimoto K; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ishikawa T; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yoshida S; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yabuki M; Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: masato.yabuki@takeda.com.
Biochem Biophys Res Commun ; 479(2): 179-185, 2016 10 14.
Article en En | MEDLINE | ID: mdl-27608596
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Pirazinas / Factor de Necrosis Tumoral alfa / Proteínas Inhibidoras de la Apoptosis / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Pirazinas / Factor de Necrosis Tumoral alfa / Proteínas Inhibidoras de la Apoptosis / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2016 Tipo del documento: Article