Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells.

Oliva, Claudia R; Markert, Tahireh; Ross, Larry J; White, E Lucile; Rasmussen, Lynn; Zhang, Wei; Everts, Maaike; Moellering, Douglas R; Bailey, Shannon M; Suto, Mark J; Griguer, Corinne E

Oliva, Claudia R; Markert, Tahireh; Ross, Larry J; White, E Lucile; Rasmussen, Lynn; Zhang, Wei; Everts, Maaike; Moellering, Douglas R; Bailey, Shannon M; Suto, Mark J; Griguer, Corinne E.

Afiliación

Oliva CR; From the Department of Neurosurgery.
Markert T; From the Department of Neurosurgery.
Ross LJ; Drug Discovery Division, Southern Research, Birmingham, Alabama 35205.
White EL; Drug Discovery Division, Southern Research, Birmingham, Alabama 35205.
Rasmussen L; Drug Discovery Division, Southern Research, Birmingham, Alabama 35205.
Zhang W; Drug Discovery Division, Southern Research, Birmingham, Alabama 35205.
Everts M; Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Moellering DR; UAB Nutrition Sciences Department, Diabetes Research Center BARB Core, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Bailey SM; Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and.
Suto MJ; Drug Discovery Division, Southern Research, Birmingham, Alabama 35205.
Griguer CE; From the Department of Neurosurgery, cegriguer@uabmc.edu.

J Biol Chem ; 291(46): 24188-24199, 2016 Nov 11.

Article en En | MEDLINE | ID: mdl-27679486

Asunto(s)

Resistencia a Antineoplásicos/efectos de los fármacos; Complejo IV de Transporte de Electrones/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Glioma; Proteínas de Neoplasias/antagonistas & inhibidores; Animales; Línea Celular Tumoral; Citocromos c/metabolismo; Complejo IV de Transporte de Electrones/metabolismo; Glioma/tratamiento farmacológico; Glioma/enzimología; Humanos; Ratones; Proteínas de Neoplasias/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

chemoresistance; cytochrome c oxidase (complex IV); glioblastoma; inhibitor; metabolism; mitochondria; small molecule; stem cells

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complejo IV de Transporte de Electrones / Resistencia a Antineoplásicos / Inhibidores Enzimáticos / Glioma / Proteínas de Neoplasias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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