A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment.

Tang, Qiao; Liu, Yajun; Li, Tao; Yang, Xiang; Zheng, Guirong; Chen, Hongning; Jia, Lee; Shao, Jingwei

Tang, Qiao; Liu, Yajun; Li, Tao; Yang, Xiang; Zheng, Guirong; Chen, Hongning; Jia, Lee; Shao, Jingwei.

Afiliación

Tang Q; Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China.
Liu Y; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, Fuzhou University, Fuzhou, China.
Li T; Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China.
Yang X; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, Fuzhou University, Fuzhou, China.
Zheng G; Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China.
Chen H; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, Fuzhou University, Fuzhou, China.
Jia L; Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, China.
Shao J; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, Fuzhou University, Fuzhou, China.

Oncotarget ; 7(45): 73114-73129, 2016 Nov 08.

Article en En | MEDLINE | ID: mdl-27683033

Asunto(s)

Aspirina/farmacología; Endotelio Vascular/metabolismo; Transición Epitelial-Mesenquimal/efectos de los fármacos; Receptores ErbB/metabolismo; Transducción de Señal/efectos de los fármacos; Triterpenos/farmacología; Animales; Aspirina/química; Biomarcadores; Adhesión Celular/efectos de los fármacos; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Modelos Animales de Enfermedad; Femenino; Expresión Génica; Xenoinjertos; Humanos; Ratones; Modelos Biológicos; Metástasis de la Neoplasia; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Neoplasias/patología; ARN Mensajero/genética; ARN Mensajero/metabolismo; Ratas; Triterpenos/química; Ácido Ursólico

Palabras clave

EGFR; EMT; aspirin; cancer metastatic chemoprevention; ursolic acid

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triterpenos / Endotelio Vascular / Transducción de Señal / Aspirina / Transición Epitelial-Mesenquimal / Receptores ErbB Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google